Negative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy

Authors

  • Abdul Hanan Nagi Departments of Pathology, University of Health Sciences, Lahore, Pakistan
  • Abu Zafar Amin Hayat Memorial Diabetic Centre, Lahore
  • Aneela Asghar Department of Biochemistry, Sahiwal Medical College, Sahiwal
  • Faheem Shahzad Department of Immunology, University of Health Sciences
  • Khursheed Javed Department of Immunology, University of Health Sciences
  • Nadeem Afzal Department of Immunology, University of Health Sciences
  • Shakeela Zaman Children Hospital and Institute of Child Health, Lahore
Abstract:

Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: In this cross-sectional casecontrol study, 212 subjects enrolled which were categorized into 3 groups. Group-I included 30 subjects without diabetes, group-II consisted of 30 subjects with T2DM without retinopathy and group-III consisted of 152 subjects with T2DM and retinopathy. Serum IL-6 and IL-17 levels were determined by ELISA. Data was analysed using SPSS 17.0 and one way ANOVA to observe group mean differences. Results: Longer mean duration of disease was detected in group-III than group-II (p=0.007). Highest IL-6 level was detected in group-II and highest IL-17 level was detected in group-I. For IL-6, significant differences were detected among groups in total, between Group-I and Group-III and between Group-II and Group-III (p

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negative association of serum il-6 and il-17 with type-ii diabetes retinopathy

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Journal title

volume 11  issue 1

pages  40- 48

publication date 2014-03-01

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